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Two of these prospective within-subject studies assessed changes in oral mucosa amongst current users, consistently reporting a reduction in pre-existing snus-associated lesions or an improvement in lesion severity over short follow-up periods ( Given the limited number of available studies, the lack of a control group in almost all current studies, the absence of long-term prospective data, and the relatively recent introduction of these products, the long-term implications of nicotine pouches in oral carcinogenesis remain unclear

The experimental norms measures can also potentially provide richer insights into intervention mechanisms to better explain variation in individuals behaviors within and between different contexts (Kimbrough and Vostroknutov, 2016

Pancreas 43 (2), 275280